Interaction between HERC1 and M2-type pyruvate kinase.

Article Details


Garcia-Gonzalo FR, Cruz C, Munoz P, Mazurek S, Eigenbrodt E, Ventura F, Bartrons R, Rosa JL

Interaction between HERC1 and M2-type pyruvate kinase.

FEBS Lett. 2003 Mar 27;539(1-3):78-84.

PubMed ID
12650930 [ View in PubMed

HERC proteins are characterized by having one or more RCC1-like domains as well as a C-terminal HECT domain in their amino acid sequences. This has led researchers to suggest that they may act as both guanine nucleotide exchange factors and E3 ubiquitin ligases. Here we describe a physical interaction between the HECT domain of HERC1, a giant protein involved in intracellular membrane traffic, and the M2 isoform of glycolytic enzyme pyruvate kinase (M2-PK). Partial colocalization of endogenous proteins was observed by immunofluorescence studies. This interaction neither induced M2-PK ubiquitination nor affected its enzymatic activity. The putative significance of the association is discussed.

DrugBank Data that Cites this Article

NameUniProt ID
Pyruvate kinase PKMP14618Details