The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

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Chen N, Rinner O, Czernik D, Nytko KJ, Zheng D, Stiehl DP, Zamboni N, Gstaiger M, Frei C

The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.

Cell Res. 2011 Jun;21(6):983-6. doi: 10.1038/cr.2011.66. Epub 2011 Apr 12.

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21483450 [ View in PubMed
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DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Pyruvate kinase PKMP14618Details
Prolyl hydroxylase EGLN3Q9H6Z9Details