Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress.
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Lombardi G, Varsaldi F, Miglio G, Papini MG, Battaglia A, Canonico PL
Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress.
Eur J Pharmacol. 2002 Dec 20;457(2-3):95-8.
- PubMed ID
- 12464354 [ View in PubMed]
- Abstract
To study if cabergoline, a long-lasting specific dopamine D2 receptor agonist, has neuroprotective effects against oxidative stress, we exposed (3 h) SH-SY5Y human neuroblastoma cells to tert-butylhydroperoxide (t-BOOH; 500 microM). t-BOOH caused a 42+/-4% neuronal death, which was prevented by cabergoline (2 h before) in a concentration-dependent manner (EC(50): 1.24 microM). This effect was not antagonised by haloperidol (concentration up to 10 microM), and was associated with an increased availability of intracellular GSH contents (+30+/-11%) and a decrease in the membrane lipid peroxidation (-23+/-9%). Our data suggest that cabergoline has neuroprotective effects useful for Parkinson's disease therapy.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cabergoline Dopamine D2 receptor Protein Humans YesAgonistDetails