[Several types of mitochondrial ultrastructure in animal cell mitochondria and their relationship to energy production].

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Mitiushin VM, Kozyreva EV

[Several types of mitochondrial ultrastructure in animal cell mitochondria and their relationship to energy production].

Tsitologiia. 1978 Apr;20(4):371-9.

PubMed ID

150666 [ View in PubMed

]

Abstract

Using the mitochondrial suspension of rabit's hepatocytes the interconnection between the ultrastructural reorganization and the power of mitochondria has been studied. Several steady states of these organelles were revealed corresponding to the rest, norm and to the excitement, all being characterized by definite ultrastructural and power-production parameters. It was shown that these physiological states of mitochondria were common to the intact cells. On the basis of the idea on the discrete physiological states of mitochondria, cases of a so-called "variety" of these methods of approach to the study of the interrelation between the structure and function of mitochondria may be used as well for the analysis of some pathological changes of these organelles.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Phenytoin	Sodium channel protein type 5 subunit alpha	Protein	Humans	Yes	Inhibitor	Details