Identification of G protein-coupled receptor genes from the human genome sequence.

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Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S

Identification of G protein-coupled receptor genes from the human genome sequence.

FEBS Lett. 2002 Jun 5;520(1-3):97-101.

PubMed ID
12044878 [ View in PubMed
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Abstract

We have identified novel G protein-coupled receptors (GPCRs) with no introns in the coding region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 registered GPCRs for endogenous ligands; 50 novel GPCR candidates homologous to registered GPCRs for endogenous ligands; and 59 novel GPCR candidates not homologous to registered GPCRs. The total number of GPCRs with and without introns in the human genome was estimated to be approximately 950, of which 500 are odorant or taste receptors and 450 are receptors for endogenous ligands.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cysteinyl leukotriene receptor 2Q9NS75Details
P2Y purinoceptor 12Q9H244Details
Hydroxycarboxylic acid receptor 2Q8TDS4Details
Sphingosine 1-phosphate receptor 5Q9H228Details
Glucose-dependent insulinotropic receptorQ8TDV5Details
Leukotriene B4 receptor 2Q9NPC1Details
G-protein coupled bile acid receptor 1Q8TDU6Details
P2Y purinoceptor 13Q9BPV8Details