Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Article Details


Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.

Science. 1995 Jul 28;269(5223):496-512.

PubMed ID
7542800 [ View in PubMed

An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.

DrugBank Data that Cites this Article

NameUniProt ID
Peptidoglycan synthase FtsIP45059Details
Penicillin-binding protein 2P44469Details
DNA gyrase subunit AP43700Details
DNA topoisomerase 4 subunit AP43702Details
UDP-N-acetylmuramate--L-alanine ligaseP45066Details
Ribosomal small subunit pseudouridine synthase AP45124Details
Shikimate dehydrogenase (NADP(+))P43876Details
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseP43777Details
Aspartate-semialdehyde dehydrogenaseP44801Details
3-deoxy-manno-octulosonate cytidylyltransferaseP44490Details
tRNA (cmo5U34)-methyltransferaseP43985Details
tRNA (cytidine(34)-2'-O)-methyltransferaseP44868Details
tRNA (guanine-N(1)-)-methyltransferaseP43912Details
Uncharacterized acyl-CoA thioester hydrolase HI_0827P44886Details
Serine acetyltransferaseP43886Details
Putative glucose-6-phosphate 1-epimeraseP44160Details
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsCP45314Details
Ribose-5-phosphate isomerase AP44725Details
Uncharacterized protein HI_0828P44887Details
50S ribosomal protein L4P44345Details
DNA ligaseP43813Details
Bifunctional protein GlmUP43889Details
Rhomboid protease GlpGP44783Details