Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Article Details
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Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Science. 1995 Jul 28;269(5223):496-512.
- PubMed ID
- 7542800 [ View in PubMed]
- Abstract
An approach for genome analysis based on sequencing and assembly of unselected pieces of DNA from the whole chromosome has been applied to obtain the complete nucleotide sequence (1,830,137 base pairs) of the genome from the bacterium Haemophilus influenzae Rd. This approach eliminates the need for initial mapping efforts and is therefore applicable to the vast array of microbial species for which genome maps are unavailable. The H. influenzae Rd genome sequence (Genome Sequence DataBase accession number L42023) represents the only complete genome sequence from a free-living organism.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Peptidoglycan synthase FtsI P45059 Details Penicillin-binding protein 2 P44469 Details DNA gyrase subunit A P43700 Details DNA topoisomerase 4 subunit A P43702 Details UDP-N-acetylmuramate--L-alanine ligase P45066 Details Ribosomal small subunit pseudouridine synthase A P45124 Details Shikimate dehydrogenase (NADP(+)) P43876 Details 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase P43777 Details Aspartate-semialdehyde dehydrogenase P44801 Details 3-deoxy-manno-octulosonate cytidylyltransferase P44490 Details tRNA (cmo5U34)-methyltransferase P43985 Details tRNA (cytidine(34)-2'-O)-methyltransferase P44868 Details tRNA (guanine-N(1)-)-methyltransferase P43912 Details Uncharacterized acyl-CoA thioester hydrolase HI_0827 P44886 Details Serine acetyltransferase P43886 Details Putative glucose-6-phosphate 1-epimerase P44160 Details 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC P45314 Details Ribose-5-phosphate isomerase A P44725 Details Uncharacterized protein HI_0828 P44887 Details 50S ribosomal protein L4 P44345 Details DNA ligase P43813 Details Bifunctional protein GlmU P43889 Details Rhomboid protease GlpG P44783 Details