Demonstration of histamine receptors on human platelets by flow cytometry.
Article Details
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Hallberg T, Dohlsten M, Baldetorp B
Demonstration of histamine receptors on human platelets by flow cytometry.
Scand J Haematol. 1984 Feb;32(2):113-8.
- PubMed ID
- 6701456 [ View in PubMed]
- Abstract
Fluoresceinated human albumin conjugated with histamine (FHA-HIS) has been used for the demonstration of histamine receptors on human platelets. Such receptors were demonstrated on 40-63% of peripheral blood platelets in 4 healthy donors. The binding of FHA-HIS was inhibited on 35-79% of the platelets by the histamine H1 receptor antagonists diphenhydramine and clemastine. The histamine H2 receptor antagonist cimetidine blocked the FHA-HIS binding on 14-37% of the platelets. It is concluded that histamine H1 as well as H2 receptors occur on human platelets but the receptors are not equally distributed in the platelet population.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Clemastine Histamine H1 receptor Protein Humans YesAntagonistDetails