ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

Article Details

Citation

Lopez-Garcia J, Periyasamy M, Thomas RS, Christian M, Leao M, Jat P, Kindle KB, Heery DM, Parker MG, Buluwela L, Kamalati T, Ali S

ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.

Nucleic Acids Res. 2006;34(21):6126-36. Epub 2006 Nov 3.

PubMed ID
17085477 [ View in PubMed
]
Abstract

The regulation of gene expression by estrogen receptor-alpha (ERalpha) requires the coordinated and temporal recruitment of diverse sets of transcriptional co-regulator complexes, which mediate nucleosome remodelling and histone modification. Using ERalpha as bait in a yeast two-hybrid screen, we have identified a novel ERalpha-interacting protein, ZNF366, which is a potent corepressor of ERalpha activity. The interaction between ZNF366 and ERalpha has been confirmed in vitro and in vivo, and is mediated by the zinc finger domains of the two proteins. Further, we show that ZNF366 acts as a corepressor by interacting with other known ERalpha corepressors, namely RIP140 and CtBP, to inhibit expression of estrogen-responsive genes in vivo. Together, our results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Estrogen receptorP03372Details
C-terminal-binding protein 1Q13363Details
Nuclear receptor-interacting protein 1P48552Details