[Receptors involved in the mechanism of action of topical prostaglandines].

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Neacsu AM

[Receptors involved in the mechanism of action of topical prostaglandines].

Oftalmologia. 2009;53(2):3-7.

PubMed ID

19697832 [ View in PubMed

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Abstract

Hypotensive effect to prostaglandins analogs (latanoprost, travoprost, tafluprost) means to increase uveoscleral outflow by action to FP receptors who generated extracellular matrix changes and intermuscular spaces changes. Syntetic prostamides analogs (bimatoprost) have a particulary action with a receptors most and intensive studied. The bimatoprost effect is the consequences to preferated stimulations on the specific receptors who have action only the tissue with prostaglandins activity is important to specify what the bimatoprost have dual effect: to uveoscleral outflow and classic outflow by increase hidraulic conductivity.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Bimatoprost	Prostaglandin F2-alpha receptor	Protein	Humans	Yes	Agonist	Details
Travoprost	Prostaglandin F2-alpha receptor	Protein	Humans	Yes	Agonist	Details