Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.
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Liebhaber SA, Goossens MJ, Kan YW
Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7054-8.
- PubMed ID
- 6452630 [ View in PubMed]
- Abstract
We have cloned one of the two human alpha-globin genes and report its complete nucleotide sequence. The gene is 832 base pairs (bp) long from the 5'-cap site to the 3'-polyadenylylation site. The amino acid coding sequences are separated into three segments (exons) by two short (117 and 140 bp) intervening sequences. Highly conserved regions are identified in the 5'-flanking region, intron-exon junctions, and 3' noncoding regions that may have functional significance.