Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.
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Adams JG 3rd, Winter WP, Rucknagel DL, Spencer HH
Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.
Science. 1972 Jun 30;176(4042):1427-9.
- PubMed ID
- 5033650 [ View in PubMed]
- Abstract
Hemoglobin Ann Arbor, in which arginine replaces leucine in position 80 of the a chain, occurs in aflected individuals in low proportion to hemoglobin A. Biosynthetic studies were perforined on reticulocytes of a patient heterozygous for this hemoglobin. These studies suggested that the low percentage of hemoglobin Ann Arbor is prinlarily due to preferential destruction of the abnormal component. The reduced concentration of alpha Ann Arbor chains was also reflected in a decreased synthesis of normal beta chains.