Hb Fukutomi [alpha 126(H9)Asp----Val]: a new hemoglobin variant with high oxygen affinity.

Article Details

Citation

Hidaka K, Iuchi I, Kobayashi T, Katoh K, Yaguchi K

Hb Fukutomi [alpha 126(H9)Asp----Val]: a new hemoglobin variant with high oxygen affinity.

Hemoglobin. 1990;14(5):499-509.

PubMed ID
2079432 [ View in PubMed
]
Abstract

Hb Fukutomi [alpha 126(H9)Asp----Val], a new hemoglobin variant with a high affinity for oxygen (log P50 = 0.201 at pH 7.0, normal = 1.087) was detected in a Japanese male during a screening survey. The amino acid substitution is located in the alpha 1 beta 1 contact of the tetramic molecule. Like other variants of the high oxygen affinity type Hb Fukutomi showed increased resistance to auto-oxidation. The tryptic peptide alpha T-13, that usually forms part of the trypsin-resistant core of the alpha chain, was cleaved off by trypsin in the new variant and released into the soluble fraction.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Hemoglobin subunit alphaP69905Details