Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2.
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Wilson JB, Webber BB, Plaseska D, de Alarcon PA, McMillan SK, Huisman TH
Hb Davenport or alpha 2(78)(EF7)Asn----His beta 2.
Hemoglobin. 1990;14(6):599-605.
- PubMed ID
- 2101836 [ View in PubMed]
- Abstract
Hb Davenport is a new, stable alpha chain variant, that was detected in two members of a Caucasian family living in Iowa. Hematological data were within normal limits. It is characterized by an Asn----His replacement at position alpha 78. Mild acidic hydrolysis of the large alpha T-9 peptide, separation of the resulting fragments by reversed phase high performance liquid chromatography, and sequence analysis of a few of these peptides greatly facilitated the identification of this substitution.