A case of complete testicular feminization: laparoscopic orchiectomy and analysis of androgen receptor gene mutation.
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Kanayama H, Naroda T, Inoue Y, Kurokawa Y, Kagawa S
A case of complete testicular feminization: laparoscopic orchiectomy and analysis of androgen receptor gene mutation.
Int J Urol. 1999 Jun;6(6):327-30.
- PubMed ID
- 10404311 [ View in PubMed]
- Abstract
BACKGROUND: Analysis of an androgen receptor gene mutation and a bilateral laparoscopic orchiectomy were performed on a 19-year-old patient diagnosed as a case of complete testicular feminization. METHODS: DNA sequencing of an androgen receptor gene mutation and laparoscopic orchiectomy were performed. RESULTS: A novel point mutation substituting a proline residue (CCG) for a leucine residue (CTG) was observed in codon 892 of exon 8 in the hormone-binding domain of the androgen receptor gene. Bilateral intra-abdominal testes were resected uneventfully by means of laparoscopic orchiectomy. CONCLUSION: We conclude that genetic analysis of androgen receptor gene mutation is essential for diagnosis of teon and laparoscopic orchiectomy is a useful therapeutic alteration as a minimally invasive treatment.