Ligands of diltiazem binding site: an overview of some chemotypes.

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Budriesi R, Ioan P, Carosati E, Cruciani G, Zhorov BS, Chiarini A

Ligands of diltiazem binding site: an overview of some chemotypes.

Mini Rev Med Chem. 2009 Oct;9(12):1379-88.

PubMed ID

19929811 [ View in PubMed

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Abstract

The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Diltiazem	Voltage-dependent calcium channel gamma-1 subunit	Protein	Humans	Yes	Blocker	Details