SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

Article Details

Citation

Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.

Sci Signal. 2012 Nov 20;5(251):ra84. doi: 10.1126/scisignal.2003431.

PubMed ID
23169818 [ View in PubMed
]
Abstract

The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels were heterodimeric assemblies of K2P1, a subunit subject to SUMOylation, and the TASK (two-P domain, acid-sensitive K(+)) channel subunits K2P3 or K2P9. The heterodimeric channels comprised the acid-sensitive portion of IKso and mediated its response to halothane. We anticipate that SUMOylation also influences sensation and homeostatic mechanisms in mammals through TASK channels formed with K2P1.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Potassium channel subfamily K member 1O00180Details
Potassium channel subfamily K member 2O95069Details
Potassium channel subfamily K member 3O14649Details
Potassium channel subfamily K member 9Q9NPC2Details