Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine.

Article Details

Citation

Zhao AL, Zhao JP, Zhang YH, Xue ZM, Chen JD, Chen XG

Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine.

Int J Neurosci. 2005 Nov;115(11):1539-47.

PubMed ID
16223700 [ View in PubMed
]
Abstract

To investigate the relationship between 48 bp variant number tandem repeat polymorphism in dopamine D4 receptor gene and response to clozapine in schizophrenic patients, the authors included 81 inpatients with a DSM-IV diagnosis of schizophrenia and patients meeting criteria for refractory to treatment were excluded. This study found that the frequencies of five 48 bp repeats homozygous genotype and five 48 bp repeats allele were significantly less in the responders than the nonresponders, which divided by improving total schizophrenic symptom. The results of this study suggest that inherited variants of D4 may explain some of the interindividual variation seen in patient response to clozapine.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ClozapineDopamine D4 receptorProteinHumans
Unknown
Antagonist
Details