Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.

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Schjelderup L, Kozlowski MR, Weissman A, Aasen AJ

Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.

Pharm Res. 1988 Apr;5(4):236-7.

PubMed ID

3247303 [ View in PubMed

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Abstract

The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Oxyphencyclimine	Muscarinic acetylcholine receptor M1	Protein	Humans	Yes	Antagonist	Details
Oxyphencyclimine	Muscarinic acetylcholine receptor M2	Protein	Humans	Yes	Antagonist	Details
Oxyphencyclimine	Muscarinic acetylcholine receptor M3	Protein	Humans	Yes	Antagonist	Details