Sequence and organization of the human mitochondrial genome.

Article Details


Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG

Sequence and organization of the human mitochondrial genome.

Nature. 1981 Apr 9;290(5806):457-65.

PubMed ID
7219534 [ View in PubMed

The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.

DrugBank Data that Cites this Article

NameUniProt ID
NADH-ubiquinone oxidoreductase chain 3P03897Details
NADH-ubiquinone oxidoreductase chain 4LP03901Details
Cytochrome c oxidase subunit 1P00395Details
NADH-ubiquinone oxidoreductase chain 6P03923Details
NADH-ubiquinone oxidoreductase chain 1P03886Details
NADH-ubiquinone oxidoreductase chain 4P03905Details
NADH-ubiquinone oxidoreductase chain 5P03915Details
NADH-ubiquinone oxidoreductase chain 2P03891Details
Cytochrome bP00156Details
Cytochrome c oxidase subunit 2P00403Details
Cytochrome c oxidase subunit 3P00414Details
ATP synthase subunit aP00846Details