Sequence and organization of the human mitochondrial genome.
Article Details
- CitationCopy to clipboard
Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG
Sequence and organization of the human mitochondrial genome.
Nature. 1981 Apr 9;290(5806):457-65.
- PubMed ID
- 7219534 [ View in PubMed]
- Abstract
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID NADH-ubiquinone oxidoreductase chain 3 P03897 Details NADH-ubiquinone oxidoreductase chain 4L P03901 Details Cytochrome c oxidase subunit 1 P00395 Details NADH-ubiquinone oxidoreductase chain 6 P03923 Details NADH-ubiquinone oxidoreductase chain 1 P03886 Details NADH-ubiquinone oxidoreductase chain 4 P03905 Details NADH-ubiquinone oxidoreductase chain 5 P03915 Details NADH-ubiquinone oxidoreductase chain 2 P03891 Details Cytochrome b P00156 Details Cytochrome c oxidase subunit 2 P00403 Details Cytochrome c oxidase subunit 3 P00414 Details ATP synthase subunit a P00846 Details