Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

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Chomyn A, Mariottini P, Cleeter MW, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolittle RF, Attardi G

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Nature. 1985 Apr 18-24;314(6012):592-7.

PubMed ID
3921850 [ View in PubMed
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Abstract

The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
NADH-ubiquinone oxidoreductase chain 3P03897Details
NADH-ubiquinone oxidoreductase chain 4LP03901Details
NADH-ubiquinone oxidoreductase chain 1P03886Details
NADH-ubiquinone oxidoreductase chain 4P03905Details
NADH-ubiquinone oxidoreductase chain 5P03915Details
NADH-ubiquinone oxidoreductase chain 2P03891Details