Barrel rotation in rats induced by SMS 201-995: suppression by ceruletide.

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Ishikawa Y, Shimatsu A, Murakami Y, Imura H

Barrel rotation in rats induced by SMS 201-995: suppression by ceruletide.

Pharmacol Biochem Behav. 1990 Nov;37(3):523-6.

PubMed ID

2087492 [ View in PubMed

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Abstract

Intracerebroventricular administration of SMS 201-995 (5 micrograms/rat), a somatostatin analogue, induced barrel rotation in rats. Pretreatment with ceruletide (40 micrograms/100 g b. wt., IP) 3 days or 7 days prior to the injection of SMS 201-995 significantly inhibited the response rate of barrel rotation induced by SMS 201-995, but not that induced by arginine-vasopressin (1 microgram/rat, ICV). The suppressive effect of ceruletide on barrel rotation could be partially countered by MK-329, a selective peripheral CCK (CCK-A) receptor antagonist. Desulfated cerulein did not affect the barrel rotation induced by SMS 201-995. These findings suggest that ceruletide specifically suppresses the barrel rotation evoked by SMS 201-995 in a long-lasting manner possibly acting through CCK-A receptor.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ceruletide	Cholecystokinin receptor type A	Protein	Humans	Yes	Inducer	Details