[Cardiac sinus node dysfunction due to a new mutation of the SCN5A gene].

Article Details

Citation

Selly JB, Boumahni B, Edmar A, Jamal Bey K, Randrianaivo H, Clerici G, Millat G, Caillet D

[Cardiac sinus node dysfunction due to a new mutation of the SCN5A gene].

Arch Pediatr. 2012 Aug;19(8):837-41. doi: 10.1016/j.arcped.2012.04.017. Epub 2012 Jul 12.

PubMed ID
22795782 [ View in PubMed
]
Abstract

A 10-year-old child was hospitalized for bradycardia during a viral infection with chikungunya. His history showed unexplored episodes of bradycardia. Cardiologic explorations revealed cardiac sinus node dysfunction (SD). Mutational screening of the SCN5A gene showed that this case was a compound heterozygote for p.Ala735Val and p.Asp1792Asn missense mutants. Five years later, the child underwent a pacemaker insertion after an electrophysiological study performed during an atrial flutter access.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Sodium channel protein type 5 subunit alphaQ14524Details