[Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction].

Article Details

Citation

Copy to clipboard

Grzelewska-Rzymowska I, Gondorowicz K, Cieslewicz G, Rozniecki J, Wojciechowska B

[Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction].

Pneumonol Alergol Pol. 1992;60(11-12):16-21.

PubMed ID

1303773 [ View in PubMed

]

Abstract

The influence of single and repeated LO (10 mg/day) doses on histamine-induced bronchoconstriction was studied in 11 patients with stabile bronchial asthma. Bronchial reactivity was estimated as histamine content potent to elicit a 20% FEV, fall, i.e. PC20H. A single dose gave a significant (5.5 fold) reduction in bronchial reactivity to inhaled histamine. Application of LO during 6 days gave a similar effect. Withdrawal of LO for 6 days yielded an increase in bronchial hyperreactivity.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Loratadine	Histamine H1 receptor	Protein	Humans	Yes	Antagonist	Details