Quinone reductase 2 is a catechol quinone reductase.

Article Details


Fu Y, Buryanovskyy L, Zhang Z

Quinone reductase 2 is a catechol quinone reductase.

J Biol Chem. 2008 Aug 29;283(35):23829-35. doi: 10.1074/jbc.M801371200. Epub 2008 Jun 24.

PubMed ID
18579530 [ View in PubMed

The functions of quinone reductase 2 have eluded researchers for decades even though a genetic polymorphism is associated with various neurological disorders. Employing enzymatic studies using adrenochrome as a substrate, we show that quinone reductase 2 is specific for the reduction of adrenochrome, whereas quinone reductase 1 shows no activity. We also solved the crystal structure of quinone reductase 2 in complexes with dopamine and adrenochrome, two compounds that are structurally related to catecholamine quinones. Detailed structural analyses delineate the mechanism of quinone reductase 2 specificity toward catechol quinones in comparison with quinone reductase 1; a side-chain rotational difference between quinone reductase 1 and quinone reductase 2 of a single residue, phenylalanine 106, determines the specificity of enzymatic activities. These results infer functional differences between two homologous enzymes and indicate that quinone reductase 2 could play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease.

DrugBank Data that Cites this Article

NameUniProt ID
Ribosyldihydronicotinamide dehydrogenase [quinone]P16083Details