Molecular phylogenetics and the origins of placental mammals.

Article Details

Citation

Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, O'Brien SJ

Molecular phylogenetics and the origins of placental mammals.

Nature. 2001 Feb 1;409(6820):614-8.

PubMed ID
11214319 [ View in PubMed
]
Abstract

The precise hierarchy of ancient divergence events that led to the present assemblage of modern placental mammals has been an area of controversy among morphologists, palaeontologists and molecular evolutionists. Here we address the potential weaknesses of limited character and taxon sampling in a comprehensive molecular phylogenetic analysis of 64 species sampled across all extant orders of placental mammals. We examined sequence variation in 18 homologous gene segments (including nearly 10,000 base pairs) that were selected for maximal phylogenetic informativeness in resolving the hierarchy of early mammalian divergence. Phylogenetic analyses identify four primary superordinal clades: (I) Afrotheria (elephants, manatees, hyraxes, tenrecs, aardvark and elephant shrews); (II) Xenarthra (sloths, anteaters and armadillos); (III) Glires (rodents and lagomorphs), as a sister taxon to primates, flying lemurs and tree shrews; and (IV) the remaining orders of placental mammals (cetaceans, artiodactyls, perissodactyls, carnivores, pangolins, bats and core insectivores). Our results provide new insight into the pattern of the early placental mammal radiation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
TyrosinaseP14679Details
Adenosine receptor A3P0DMS8Details
Brain-derived neurotrophic factorP23560Details
Copper-transporting ATPase 1Q04656Details