Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.

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Capasso A, Sorrentino L

Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum.

Eur J Pharmacol. 1997 Jul 9;330(2-3):199-204.

PubMed ID

9253954 [ View in PubMed

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Abstract

The effects of phospholipase A2, cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase inhibitors were investigated on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum in vitro. Mepacrine (a phospholipase A2 inhibitor), tolmetin (selective cyclooxygenase-1 inhibitor) and meloxicam (selective cyclooxygenase-2 inhibitor) treatment before or after morphine was able to both prevent and reverse the naloxone-induced contracture after exposure to morphine in a concentration-dependent fashion. Also, nordihydroguaiaretic acid (5-lipooxygenase inhibitor) was able to block the naloxone-induced contracture following exposure to morphine when injected before or after the opioid agonist. The results of the present study suggest that arachidonic acid and its metabolites (prostaglandins and leukotrienes) are involved in the development of opioid withdrawal.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tolmetin	Prostaglandin G/H synthase 1	Protein	Humans	Unknown	Inhibitor	Details
Tolmetin	Prostaglandin G/H synthase 2	Protein	Humans	Yes	Inhibitor	Details