X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir.

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Das A, Rao DR, Hosur MV

X-ray structure of HIV-1 protease tethered dimer complexed to ritonavir.

Protein Pept Lett. 2007;14(6):565-8.

PubMed ID

17627597 [ View in PubMed

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Abstract

We report here the 2.5A structure of HIV-1 protease tethered-dimer ritonavir complex. The inhibitor bound in the active site has different conformations in the two orientations. There is only one hydrogen bond between the inhibitor and the enzyme. The conserved flap-water is not found in the present complex.

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Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ritonavir	Human immunodeficiency virus type 1 protease	Protein	Human immunodeficiency virus 1	Yes	Inhibitor	Details