Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

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Citation

Malfroy B, Kuang WJ, Seeburg PH, Mason AJ, Schofield PR

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

FEBS Lett. 1988 Feb 29;229(1):206-10.

PubMed ID
3162217 [ View in PubMed
]
Abstract

We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase, EC 3.4.24.11) in a lambda gt10 library from human placenta, and present the complete 742 amino acid sequence of human enkephalinase. The human enzyme displays a high homology with rat and rabbit enkephalinase. Like the rat and rabbit enzyme, human enkephalinase contains a single N-terminal transmembrane region and is likely to be inserted through cell membranes with the majority of protein, including its carboxy-terminus, located extracellularly.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
NeprilysinP08473Details