Antithrombin Rouen-IV 24 Arg----Cys. The amino-terminal contribution to heparin binding.

Article Details

Citation

Borg JY, Brennan SO, Carrell RW, George P, Perry DJ, Shaw J

Antithrombin Rouen-IV 24 Arg----Cys. The amino-terminal contribution to heparin binding.

FEBS Lett. 1990 Jun 18;266(1-2):163-6.

PubMed ID
2365065 [ View in PubMed
]
Abstract

A variant antithrombin with reduced heparin affinity was shown by mass spectrometry sequencing and DNA amplification to have a substitution of a cysteine for an arginine at residue 24. The position of Arg-24 can be fixed within a 12 A radius from the bridge at Cys-21. This is compatible with findings in the homologous protease nexin-1 which indicate an extension of the binding site of heparin from the D-helix to under the adjacent amino-terminal pole.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Antithrombin-IIIP01008Details