COX-2-specific inhibition: implications for clinical practice.

Article Details

Citation

Pascucci RA

COX-2-specific inhibition: implications for clinical practice.

J Am Osteopath Assoc. 1999 Nov;99(11 Suppl):S18-22.

PubMed ID
10643177 [ View in PubMed
]
Abstract

Although conventional nonsteroidal anti-inflammatory drugs (NSAIDs) have long been a major therapeutic choice for the management of arthritic conditions, the potential adverse effects of these agents sometimes compromise their clinical utility. New modes of therapy have recently been introduced, and data on the cyclooxygenase-2 (COX-2)-specific inhibitors celecoxib and rofecoxib suggest that these agents will meet the need for safe and effective therapeutic alternatives to conventional NSAIDs.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
RofecoxibProstaglandin G/H synthase 2ProteinHumans
Yes
Inhibitor
Details