5-HT1A receptor-regulated signal transduction pathways in brain.
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Polter AM, Li X
5-HT1A receptor-regulated signal transduction pathways in brain.
Cell Signal. 2010 Oct;22(10):1406-12. doi: 10.1016/j.cellsig.2010.03.019. Epub 2010 Apr 2.
- PubMed ID
- 20363322 [ View in PubMed]
- Abstract
Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors.