Tailor-made chemotherapy for non-small cell lung cancer patients.

Article Details

Citation

Huang CL, Yokomise H, Fukushima M, Kinoshita M

Tailor-made chemotherapy for non-small cell lung cancer patients.

Future Oncol. 2006 Apr;2(2):289-99.

PubMed ID
16563096 [ View in PubMed
]
Abstract

The selection of the most effective chemotherapy treatment based on evaluation of biomarkers, that is, 'tailor-made chemotherapy', can improve the clinical outcome of non-small cell lung cancer patients, including early-stage tumors with a high metastatic potential and advanced-stage tumors with a low proliferation rate. Therefore, treatment would be chosen according to which drugs would be most effective in combating specific tumors. For example: 5-fluorouracil-derived agents would be used for tumors with a low expression of thymidylate synthase; gefitinib and erlotinib for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers; cisplatin and carboplatin for tumors with a low expression of excision repair cross complementing-1; and gemcitabine for tumors with a low expression of ribonucleotide reductase. The remaining populations of non-small cell lung cancers require chemotherapy using other drugs based on an evaluation of other targeted molecules.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
FluorouracilThymidylate synthaseProteinHumans
Yes
Other/unknown
Details
GemcitabineThymidylate synthaseProteinHumans
Unknown
Inhibitor
Details