Crystallographic refinement of human serum retinol binding protein at 2A resolution.

Article Details

Citation

Cowan SW, Newcomer ME, Jones TA

Crystallographic refinement of human serum retinol binding protein at 2A resolution.

Proteins. 1990;8(1):44-61.

PubMed ID
2217163 [ View in PubMed
]
Abstract

Human serum retinol binding protein (RBP) in complex with retinol has been crystallographically refined to an R-factor of 18.1% with 2A resolution data. The protein topology results in an anti-parallel beta-barrel that encapsulates the retinol ligand. A detailed description of the protein and the binding site is provided. Our structural work has helped to define a family of proteins, many of which are carrier proteins for smaller ligand molecules. We describe the structural basis for the conservation of sequence within the family.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Retinol-binding protein 4P02753Details