Structural determinants of nuclear receptor assembly on DNA direct repeats.

Article Details

Citation

Rastinejad F, Perlmann T, Evans RM, Sigler PB

Structural determinants of nuclear receptor assembly on DNA direct repeats.

Nature. 1995 May 18;375(6528):203-11.

PubMed ID
7746322 [ View in PubMed
]
Abstract

Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Thyroid hormone receptor betaP10828Details
Retinoic acid receptor RXR-alphaP19793Details