Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
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Aaron JA, Chambers JM, Jude KM, Di Costanzo L, Dmochowski IJ, Christianson DW
Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
J Am Chem Soc. 2008 Jun 4;130(22):6942-3. doi: 10.1021/ja802214x. Epub 2008 May 8.
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- 18461940 [ View in PubMed]
- Abstract
Cryptophanes represent an exciting class of xenon-encapsulating molecules that can be exploited as probes for nuclear magnetic resonance imaging. The 1.70 A resolution crystal structure of a cryptophane-derivatized benezenesulfonamide complexed with human carbonic anhydrase II shows how an encapsulated xenon atom can be directed to a specific biological target. The crystal structure confirms binding measurements indicating that the cryptophane cage does not strongly interact with the surface of the protein, which may enhance the sensitivity of 129Xe NMR spectroscopic measurements in solution.