Fibroblast growth factor signalling: from development to cancer.

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Turner N, Grose R

Fibroblast growth factor signalling: from development to cancer.

Nat Rev Cancer. 2010 Feb;10(2):116-29. doi: 10.1038/nrc2780.

PubMed ID
20094046 [ View in PubMed
]
Abstract

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. Although targeting FGF signalling as a cancer therapeutic target has lagged behind that of other receptor tyrosine kinases, there is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed. Although FGF signalling can drive tumorigenesis, in different contexts FGF signalling can mediate tumour protective functions; the identification of the mechanisms that underlie these differential effects will be important to understand how FGF signalling can be most appropriately therapeutically targeted.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Fibroblast growth factor 4P08620Details
Fibroblast growth factor 1P05230Details
Fibroblast growth factor receptor 2P21802Details
Fibroblast growth factor 2P09038Details
Fibroblast growth factor receptor 4P22455Details
Fibroblast growth factor receptor 1P11362Details
Fibroblast growth factor receptor 3P22607Details
Fibroblast growth factor 19O95750Details