Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein.

Article Details

Citation

Monaco HL, Rizzi M, Coda A

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein.

Science. 1995 May 19;268(5213):1039-41.

PubMed ID
7754382 [ View in PubMed
]
Abstract

The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
TransthyretinP02766Details