Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.

Article Details

Citation

Richards DM, Brogden RN, Heel RC, Speight TM, Avery GS

Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy.

Drugs. 1984 Jul;28(1):38-61.

PubMed ID
6204835 [ View in PubMed
]
Abstract

Astemizole is an H1-histamine receptor antagonist with a long duration of action permitting once daily administration. Its efficacy in seasonal and perennial allergic rhinitis has been convincingly demonstrated, and several comparative studies suggest that astemizole is at least as effective as some other H1-histamine receptor antagonists. A few smaller studies have shown beneficial effects on the symptoms of allergic conjunctivitis and chronic urticaria (but not atopic dermatitis). While astemizole appears to share with other H1-histamine receptor antagonists a tendency to increase appetite and cause weight gain after prolonged use, it offers the important advantage of an absence of significant central nervous system depression or anticholinergic effects with usual doses. Thus, astemizole offers a worthwhile improvement in side effect profile over 'traditional' H1-histamine receptor antagonists, especially in patients bothered by the sedative effects of these drugs.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AstemizoleHistamine H1 receptorProteinHumans
Yes
Antagonist
Details