Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.

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Citation

Chen YM, Chen LY, Wong FH, Lee CM, Chang TJ, Yang-Feng TL

Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene.

Genomics. 2000 May 15;66(1):43-7.

PubMed ID
10843803 [ View in PubMed
]
Abstract

The glycine N-methyltransferase (GNMT) gene encodes a protein that not only acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine, but also participates in the detoxification pathway in liver cells. Previously, we reported that the expression level of GNMT was diminished in human hepatocellular carcinoma. In this study, the human GNMT gene was cloned and characterized. It contains six exons and spans about 10 kb. Instead of a TATA box, it has a transcriptional initiator located 801 bp upstream from the translation start codon. The gene was localized to chromosome 6p12 using fluorescence in situ hybridization. Northern blot analysis of 16 tissues from different human organs showed that GNMT was expressed only in liver, pancreas, and prostate.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Glycine N-methyltransferaseQ14749Details