Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
Article Details
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Zohar J, Kennedy JL, Hollander E, Koran LM
Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
J Clin Psychiatry. 2004;65 Suppl 14:18-21.
- PubMed ID
- 15554784 [ View in PubMed]
- Abstract
Support for the serotonin-1D (5-HT(1D)) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT(1D) agonist sumatriptan, and case reports in which prolonged administration of 5-HT(1D) agonists was associated with a therapeutic effect, suggest that 5-HT(1D) may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT(1D) gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Sumatriptan 5-hydroxytryptamine receptor 1D Protein Humans YesAgonistDetails