Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.

Article Details

Citation

Zohar J, Kennedy JL, Hollander E, Koran LM

Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.

J Clin Psychiatry. 2004;65 Suppl 14:18-21.

PubMed ID
15554784 [ View in PubMed
]
Abstract

Support for the serotonin-1D (5-HT(1D)) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT(1D) agonist sumatriptan, and case reports in which prolonged administration of 5-HT(1D) agonists was associated with a therapeutic effect, suggest that 5-HT(1D) may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT(1D) gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Sumatriptan5-hydroxytryptamine receptor 1DProteinHumans
Yes
Agonist
Details