[Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases].

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Tonkopii VD, Prozorovskii VB, Suslova IM

[Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases].

Biull Eksp Biol Med. 1976 Aug;82(8):947-50.

PubMed ID

1026294 [ View in PubMed

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Abstract

The kinetics of inhibition of the human red blood cell cholinesterase with galanthamine tacrine and oxazyl (ambenonium) and the effect of these drugs on chick, mouse, cat and rat blood plasma enzyme activity was studied. Galanthamine proved to bind with acetylcholinesterase in the anionic areas of the catalytic centres, oxazyl interacted in the area of the allosteric anionic site, and tacrin interacted with the hydrophobic areas of the enzyme.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Galantamine	Acetylcholinesterase	Protein	Humans	Yes	Inhibitor	Details