[The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats].

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Citation

Guan J, Cheng DY, Chen XJ, Zhang Y, Wang H, Su QL

[The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats].

Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Nov;35(6):774-7.

PubMed ID
15573751 [ View in PubMed
]
Abstract

OBJECTIVE: To investigate the effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats. METHODS: Thirty male SD rats were randomly divided into three groups: control group, hypoxic group and therapeutic group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for three weeks. Then, the therapeutic group was given losartan for two weeks. We measured the expression of Collagen I, III and AT1 in arterioles by means of immunohistochemistry. RESULTS: The positive degree of Collagen I in pulmonary arterioles in the hypoxic group was higher than that in the control group [(1.5202+/-0.069) vs (1.1324+/-0.071), P<0.01]; but in the therapeutic group it was lower than that in the hypoxic group [(1.1637+/-0.062) vs (1.5202+/-0.069), P<0.01]. There was no significant difference in collagen III and AT1 among the three groups (P>0.05). CONCLUSION: Losartan could reduce pulmonary arterial collagen I expression, it may be one of the therapeutic mechanisms on hypoxic pulmonary hypertension of losartan.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
LosartanType-1 angiotensin II receptorProteinHumans
Yes
Antagonist
Details