[Potentiation of the photocytotoxic effect of photofrin II: synergistic action of verapamil and lovastatin].

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Maziere JC, Mora L, Biade S, Maziere C, Santus R

[Potentiation of the photocytotoxic effect of photofrin II: synergistic action of verapamil and lovastatin].

Bull Acad Natl Med. 1994 Jun;178(6):1177-88; discussion 1188-9.

PubMed ID

7994588 [ View in PubMed

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Abstract

Photofrin II (P2) is at the present time the most used drug in the photochemotherapy of tumors. As previous studies from our group have demonstrated that P2 is taken up by cells mainly via the low density lipoprotein (LDL) receptor pathway, we tried to increase the amount of drug delivered to cells by enhancing the LDL receptor expression. For this purpose, we used hydroxy methyl glutaryl Coenzyme A (HMG-CoA) reductase inhibitors such as lovastatin. In the present work, we show that the calcium antagonist verapamil, which is currently used in human chemotherapy to overcome multidrug resistance, enhances in a synergistic manner the potentiating action of lovastatin on the photocytotoxic effect of P2.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Porfimer sodium	Low-density lipoprotein receptor	Protein	Humans	Unknown	Other/unknown	Details