Mechanisms of retroviral recombination.

Article Details


Negroni M, Buc H

Mechanisms of retroviral recombination.

Annu Rev Genet. 2001;35:275-302.

PubMed ID
11700285 [ View in PubMed

Recombination is a major source of genetic variability in retroviruses. Each viral particle contains two single-stranded genomic RNAs. Recombination mostly results from a switch in template between these two RNAs during reverse transcription. Here we emphasize the main mechanisms underlying recombination that are emerging from recent advances in biochemical and cell culture techniques. Increasing evidence supporting the involvement of RNA secondary structures now complements the predominant role classically attributed to enzyme pausing during reverse transcription. Finally, the implications of recombination on the dynamics of emergence of genomic aberrations in retroviruses are discussed.

DrugBank Data that Cites this Article

NameUniProt ID
Gag-Pol polyproteinP03369Details
Gag-Pol polyproteinP12497Details
Gag-Pol polyproteinP35963Details
Gag-Pol polyproteinP12499Details
Gag-Pol polyproteinP04585Details
Gag-Pol polyproteinP04584Details
Gag-Pol polyproteinP03366Details
Gag-Pol polyproteinP03367Details
Gag-Pol polyproteinP04587Details