Mechanisms of retroviral recombination.
Article Details
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Negroni M, Buc H
Mechanisms of retroviral recombination.
Annu Rev Genet. 2001;35:275-302.
- PubMed ID
- 11700285 [ View in PubMed]
- Abstract
Recombination is a major source of genetic variability in retroviruses. Each viral particle contains two single-stranded genomic RNAs. Recombination mostly results from a switch in template between these two RNAs during reverse transcription. Here we emphasize the main mechanisms underlying recombination that are emerging from recent advances in biochemical and cell culture techniques. Increasing evidence supporting the involvement of RNA secondary structures now complements the predominant role classically attributed to enzyme pausing during reverse transcription. Finally, the implications of recombination on the dynamics of emergence of genomic aberrations in retroviruses are discussed.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Gag-Pol polyprotein P03369 Details Gag-Pol polyprotein P12497 Details Gag-Pol polyprotein P35963 Details Gag-Pol polyprotein P12499 Details Gag-Pol polyprotein P04585 Details Gag-Pol polyprotein P04584 Details Gag-Pol polyprotein P03366 Details Gag-Pol polyprotein P03367 Details Gag-Pol polyprotein P04587 Details