Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle.

Article Details

Citation

George N, Shiny PJ, Miriam J, Nancy CA, Dhanasekar KR, Peedicayil J

Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle.

Auton Autacoid Pharmacol. 2010 Jul;30(3):173-7. doi: 10.1111/j.1474-8673.2009.00447.x. Epub 2010 Jan 19.

PubMed ID
20085574 [ View in PubMed
]
Abstract

This study investigated whether four anticholinergics which are not clinically used for relaxing the urinary bladder detrusor muscle inhibit the contraction of isolated caprine (goat) detrusor muscle: cyclopentolate (100 nm), homatropine (5 microm), ipratropium (500 nm) and valethamate (1 microm). The effects of these anticholinergics were compared with tolterodine (3 microm), an anticholinergic clinically used for relaxing the detrusor muscle. The inhibitory effect of each of these five anticholinergics was studied on six strips of caprine detrusor muscle made to contract with 100 mum acetylcholine (ACh) by determining the percent inhibition of height of contraction and the area under the contractile curve (AUC). It was found that all five anticholinergics inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh. Hence, these four anticholinergics, like tolterodine, may be useful in managing clinical conditions that require relaxation of the detrusor muscle.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Homatropine methylbromideMuscarinic acetylcholine receptor M1ProteinHumans
Yes
Antagonist
Details
Homatropine methylbromideMuscarinic acetylcholine receptor M2ProteinHumans
Yes
Antagonist
Details