The protooncogene TCL1 is an Akt kinase coactivator.

Article Details


Laine J, Kunstle G, Obata T, Sha M, Noguchi M

The protooncogene TCL1 is an Akt kinase coactivator.

Mol Cell. 2000 Aug;6(2):395-407.

PubMed ID
10983986 [ View in PubMed

Human T cell prolymphocytic leukemia can result from chromosomal translocations involving 14q32.1 or Xq28 regions. The regions encode a family of protooncogenes (TCL1, MTCP1, and TCL1b) of unknown function. In yeast two-hybrid screening, we found that TCL1 interacts with Akt. All TCL1 isoforms bind to the Akt pleckstrin homology domain. Both in vitro and in vivo TCL1 increases Akt kinase activity and as a consequence enhances substrate phosphorylation. In vivo, TCL1 stabilizes the mitochondrial transmembrane potential and enhances cell proliferation and survival. In vivo, TCL1 forms trimers, which associate with Akt. TCL1 facilitates the oligomerization and activation of Akt. Our data show that TCL1 is a novel Akt kinase coactivator, which promotes Akt-induced cell survival and proliferation.

DrugBank Data that Cites this Article

NameUniProt ID
RAC-alpha serine/threonine-protein kinaseP31749Details
RAC-beta serine/threonine-protein kinaseP31751Details