Spectrophotometric determination of carbinoxamine maleate in pharmaceutical formulations by ternary complex formation with Cu(II) and eosin.

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Citation

Ramadan AA, Mandil H

Spectrophotometric determination of carbinoxamine maleate in pharmaceutical formulations by ternary complex formation with Cu(II) and eosin.

Anal Biochem. 2006 Jun 1;353(1):133-7. Epub 2006 Mar 9.

PubMed ID
16574052 [ View in PubMed
]
Abstract

A simple and sensitive spectrophotometric method was developed for the determination of carbinoxamine maleate in pharmaceutical formulations. The method is based on the formation of a ternary complex, extractable with chloroform, between copper(II), eosin, and carbinoxamine maleate. The absorption spectra of the ternary complexes shows, under optimum conditions, a maxima at 538 nm, with apparent molar absorptive 6.1690 x 10(4) mol(-1) cm(-1), Sandell's sensitives 6.75 x 10(-3) microg cm(-2), and linearity in the concentration range 0.75-10.0 microg ml(-1). The method can be achieved with high accuracy (recovery values, 100 +/- 2%) and precision (with standard deviation 0.029-0.155 and relative standard deviation 3.87-1.55%). The method was again successfully applied, with high accuracy and good precision, for the determination of carbinoxamine maleate in various pharmaceutical formulations (syrup, drops, and tablets).

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CarbinoxamineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details