The protein kinase complement of the human genome.

Article Details


Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S

The protein kinase complement of the human genome.

Science. 2002 Dec 6;298(5600):1912-34.

PubMed ID
12471243 [ View in PubMed

We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons.

DrugBank Data that Cites this Article

NameUniProt ID
Cyclin-dependent kinase 15Q96Q40Details
Ankyrin repeat and protein kinase domain-containing protein 1Q8NFD2Details
Myosin light chain kinase family member 4Q86YV6Details
Uncharacterized serine/threonine-protein kinase SBK3P0C264Details
Serine/threonine-protein kinase 32AQ8WU08Details