Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

Article Details

Citation

Corti O, DiDonato S, Finocchiaro G

Divergent sequences in the 5' region of cDNA suggest alternative splicing as a mechanism for the generation of carnitine acetyltransferases with different subcellular localizations.

Biochem J. 1994 Oct 1;303 ( Pt 1):37-41.

PubMed ID
7945262 [ View in PubMed
]
Abstract

We identified two partially overlapping cDNAs containing divergent 5' sequences of human carnitine acetyltransferase (CAT). cDNA lambda SM-1400 extends the sequence of peroxisomal CAT, whereas cDNA lambda SM-1200 creates a new open reading frame encoding a putative mitochondrial leader peptide. An intron is located where sequences diverge, suggesting that mitochondrial, peroxisomal and possibly endoplasmic reticulum CAT mRNAs derive from alternative splicing of the CAT gene.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Carnitine O-acetyltransferaseP43155Details