Changes in brain gene expression shared by scrapie and Alzheimer disease.
Article Details
- CitationCopy to clipboard
Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW
Changes in brain gene expression shared by scrapie and Alzheimer disease.
Proc Natl Acad Sci U S A. 1989 Sep;86(18):7260-4.
- PubMed ID
- 2780570 [ View in PubMed]
- Abstract
We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.